BMSQABSE: Design of a Bioinspired Model to Improve Security & QoS Performance for Blockchain-Powered Attribute-based Searchable Encryption Applications

Attribute-based searchable encryption (ABSE) is a sub-field of security models that allow intensive searching capabilities for cloud-based shared storage applications. ABSE Models require higher computational power, which limits their application to high-performance computing devices. Moreover, ABSE uses linear secret sharing scheme (LSSS), which requires larger storage when compared with traditional encryption models. To reduce computational complexity, and optimize storage cost, various researchers have proposed use of Machine Learning Models (MLMs), that assist in identification & removal of storage & computational redundancies. But most of these models use static reconfiguration, thus cannot be applied to large-scale deployments. To overcome this limitation, a novel combination of Grey Wolf Optimization (GWO) with Particle Swarm Optimization (PSO) model to improve Security & QoS performance for Blockchain-powered Attribute-based Searchable Encryption deployments is proposed in this text. The proposed model augments ABSE parameters to reduce its complexity and improve QoS performance under different real-time user request scenarios. It intelligently selects cyclic source groups with prime order & generator values to create bilinear maps that are used for ABSE operations. The PSO Model assists in generation of initial cyclic population, and verifies its security levels, QoS levels, and deployment costs under multiple real-time cloud scenarios. Based on this initial analysis, the GWO Model continuously tunes ABSE parameters in order to achieve better QoS & security performance levels via stochastic operations. The proposed BMSQABSE model was tested under different cloud configurations, and its performance was evaluated for healthcare deployments. Based on this evaluation, it was observed that the proposed model achieved 8.3% lower delay, with 4.9% lower energy consumption, 14.5% lower storage requirements when compared with standard ABSE models. It was able to mitigate Distributed Denial of Service (DDoS), Masquerading, Finney, and Sybil attacks, which assists in deploying the proposed model for QoS-aware highly secure deployments

Haploidentical vs. sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia

The role of haploidentical hematopoietic cell transplantation (HCT) using posttransplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariable analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) among haploidentical HCTs using PTCy and HLA-matched sibling donor (MSD), 8/8 HLAmatched unrelated donor (MUD), 7 /8 HLA-MUD, or umbilical cord blood (UCB) HCT. Comparing haploidentical HCT to MSD HCT, we found that OS, leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and acute graft-versus-host disease (aGVHD) were not different but chronic GVHD (cGVHD) was higher in MSD HCT. Compared with MUD HCT, OS, LFS, and relapse were not different, but MUD HCT had increased NRM (hazard ratio [HR], 1.42; P = .02), grade 3 to 4 aGVHD (HR, 1.59; P = .005), and cGVHD. Compared with 7/8 UD HCT, LFS and relapse were not different, but 7/8 UD HCT had worse OS (HR, 1.38; P = .01) and increased NRM (HR, 2.13; P <_ .001), grade 3 to 4 aGVHD (HR, 1.86; P = .003), and cGVHD (HR, 1.72; P <_ .001). Compared with UCB HCT, late OS, late LFS, relapse, and cGVHD were not different but UCB HCT had worse early OS (<_18 months; HR, 1.93; P < .001), worse early LFS (HR, 1.40; P = .007) and increased incidences of NRM (HR, 2.08; P < .001) and grade 3 to 4 aGVHD (HR, 1.97; P < .001). Haploidentical HCT using PTCy showed no difference in survival but less GVHD compared with traditional MSD and MUD HCT and is the preferred alternative donor HCT option for adults with ALL in complete remission

Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide

Post-transplant cyclophosphamide (PTCy) has significantly increased the successful use of haploidentical donors with a relatively low incidence of graft-versus-host disease (GVHD). Given its increasing use, we sought to determine risk factors for GVHD after haploidentical hematopoietic cell transplantation (haplo-HCT) using PTCy. Data from the Center for International Blood and Marrow Transplant Research on adult patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, or chronic myeloid leukemia who underwent PTCy-based haplo-HCT (2013 to 2016) were analyzed and categorized into 4 groups based on myeloablative (MA) or reduced-intensity conditioning (RIC) and bone marrow (BM) or peripheral blood (PB) graft source. In total, 646 patients were identified (MA-BM = 79, MA-PB = 183, RIC-BM = 192, RIC-PB = 192). The incidence of grade 2 to 4 acute GVHD at 6 months was highest in MA-PB (44%), followed by RIC-PB (36%), MA-BM (36%), and RIC-BM (30%) (P = .002). The incidence of chronic GVHD at 1 year was 40%, 34%, 24%, and 20%, respectively (P < .001). In multivariable analysis, there was no impact of stem cell source or conditioning regimen on grade 2 to 4 acute GVHD; however, older donor age (30 to 49 versus <29 years) was significantly associated with higher rates of grade 2 to 4 acute GVHD (hazard ratio [HR], 1.53; 95% confidence interval [CI], 1.11 to 2.12; P = .01). In contrast, PB compared to BM as a stem cell source was a significant risk factor for the development of chronic GVHD (HR, 1.70; 95% CI, 1.11 to 2.62; P = .01) in the RIC setting. There were no differences in relapse or overall survival between groups. Donor age and graft source are risk factors for acute and chronic GVHD, respectively, after PTCy-based haplo-HCT. Our results indicate that in RIC haplo-HCT, the risk of chronic GVHD is higher with PB stem cells, without any difference in relapse or overall survival

Structural characterization and photocatalytic properties of hydrothermally synthesized Ni²⁺-TiO₂ nanoparticles for dye degradation under direct sunlight

479-487ANi2+-TiO2 photocatalyst, efficient and highly active in sunlight has been prepared by a simple hydrothermal method using titanium isopropoxide (TTIP) precursor. The synthesized nanoparticles (NPs) have been analysed to determine its structural, optical, morphological and compositional properties using X-ray diffraction, Raman, UV-DRS, photoluminescence, XPS, TEM and EDS. The EDS micrograph confirms the existence of Ni2+ atoms (0.65, 1.32 and 1.60 wt.%) in the TiO2 matrix. The average particle size obtained from TEM is 8-11 nm and is in good agreement with XRD results. Raman bands at 641.44 cm-1, 517.42 cm-1 and 398.43 cm-1 further confirm pure phase anatase in all samples. XPS shows the substitution of Ti4+ ions by Ni2+ ions in the TiO2 host lattice. The photocatalytic activity of these nanoparticles have been studied using malachite green dye under UV light, visible light and direct sunlight. The crystallite size and band gap decreases with increase in Ni2+ concentration which increase its catalytic activity under sunlight. The photocatalyst, Ni2+-TiO2 (1.60 wt.%), shows excellent photocatalytic activity in the visible and direct sunlight and hence it is a promising for environmental friendly photocatalytic applications

A rare case of schizencephaly in an adult with late presentation

Schizencephaly, i.e., split brain, is a rare, congenital cerebral malformation. Magnetic resonance imaging is the best neuroimaging modality for its diagnosis. In literature, only few cases have been reported causing symptoms in adults. Symptomatic patients present as hemiparesis, developmental deficits to seizures. This condition is usually found at birth and presents during early years. Appropriate diagnosis of the disease is necessary to avoid incorrect treatment. Here, we present a rare case of left, unilateral, open lip schizencephaly in an adult patient presenting with partial seizures but with an asymptomatic childhood

An Interesting Journey of an Endobronchial Foreign Body - A Case Report

Reported incidence of spontaneous expulsion of chronically impacted foreign body from a segmental bronchiole is very less. We report a rare and fascinating journey of an iron nail which was accidentally inhaled two years back and was there in the right lateral basal segmental bronchiole. During bronchoscopy with severe bout of cough, the foreign body was expelled out through the bronchus and it was found to lie at unusual location i.e. in the rectum In most of the reported cases of foreign body inhalation and their expulsion, the foreign bodies were in right or left main bronchus, however in our case it is in the segmental bronchiole. Duration of the history in our case is two years, however duration in most of the reported cases is maximum of 11 months, and this makes our case exceptional. Route of expulsion of foreign body in our case is per rectal which is not mentioned in the literature. Imaging played a vital role in our case to locate the impacted as well as expelled endo-bronchial foreign bod